What the research tells us about low downtime protocols
DERMATOLOGIC SURGERY · 2024
A multi-session, low-density fractional CO₂ approach was found to produce clinically significant improvements in acne scar appearance with a substantially reduced downtime profile compared to single-session ablative treatments.
Shenhav L, et al. Fractional CO₂ laser resurfacing for acne scars: a multi-session low-density approach.
JOURNAL OF COSMETIC DERMATOLOGY · 2025
Comparative analysis of fractionated versus ablative CO₂ protocols demonstrated that cumulative low-density sessions produced outcomes equivalent to single high-density procedures for photoageing and acne scarring, with a markedly improved side-effect profile.
Levy LL, et al. Comparative outcomes of fractionated versus ablative CO₂ resurfacing protocols. J Cosmet Dermatol.
LASERS IN SURGERY & MEDICINE · 2004
The foundational study establishing fractional photothermolysis demonstrated that microscopic patterns of controlled thermal injury stimulate effective dermal remodelling while sparing surrounding tissue, providing the mechanistic basis for modern fractional CO₂ treatments.
Manstein D, et al. Fractional photothermolysis: a new concept for cutaneous remodelling using microscopic patterns of thermal injury.
Research is referenced for educational purposes and to support transparency in our clinical decision-making. Individual treatment outcomes vary. Peer-reviewed evidence does not guarantee specific results for any individual.